Wholesale · Cosmetic peptide
Wholesale Matrixyl (Palmitoyl Pentapeptide-4)
The benchmark matrikine peptide for collagen-support formulation, manufactured to GMP standard at ≥98% HPLC purity with a batch COA included. A different mechanism from expression-line peptides — and one that formulates alongside them rather than competing. Supplied wholesale and white label across Europe and internationally.
Overview
A matrikine peptide, not an expression-line peptide
Matrixyl is the trade name for Palmitoyl Pentapeptide-4 — commonly written as pal-KTTKS — originated by Sederma. Its peptide portion, KTTKS, is a subfragment of type I procollagen. Fragments of this kind are known as matrikines: signalling molecules that the skin recognises as markers of matrix turnover.
That mechanism is what distinguishes it commercially. Argireline and SNAP-8 target SNAP-25 and are positioned around expression lines. Matrixyl works through an entirely different route, in the collagen-support and skin-firmness space. The two categories complement rather than compete, which is why multi-peptide serums so often contain one from each.
SARMs-Direct supplies wholesale Matrixyl as powder or solution to skincare brands, cosmetic manufacturers, ingredient distributors, formulation laboratories and private label buyers. All supply is GMP-certified with full batch documentation and a COA included.
Different mechanism
Matrikine signalling — complements expression-line peptides rather than duplicating them.
Very low use levels
Active at parts-per-million, giving favourable cost-in-use.
Lipophilic
The palmitoyl chain aids delivery but affects solubility — see the formulation notes.
Compound specifications
Matrixyl at a glance
| Product name | Matrixyl (trade name) |
| INCI name | Palmitoyl Pentapeptide-4 |
| Former INCI | Palmitoyl Pentapeptide-3 (still seen) |
| Common shorthand | pal-KTTKS |
| CAS number | 214047-00-4 |
| Compound class | Palmitoylated cosmetic pentapeptide (matrikine) |
| Sequence | Palmitoyl-Lys-Thr-Thr-Lys-Ser |
| Molecular formula | C₃₉H₇₅N₇O₁₀ |
| Molecular weight | ≈802.1 g/mol |
| Purity | ≥98% (HPLC verified) |
| Appearance | White to off-white powder |
| Solubility | Lipophilic — limited water solubility as neat powder |
| Storage | Cool, dry place. Protect from light and moisture. Refrigerate for long-term storage. |
Available quantities
Supply options
1g
Sample / trial
10g
Small batch
100g
Standard
1kg+
Bulk
- ✓ Powder or solution — solution simplifies dosing given the low use levels involved. Specify which suits your process.
- ✓ Standard quantities from 1g to 1kg and larger bulk, with custom quotations by volume and supply frequency.
- ✓ White & private label supply for skincare brands and cosmetic manufacturers.
- ✓ Samples available for formulation trials — mention it in your enquiry.
Building a peptide range
Which peptide does what
We supply four cosmetic peptides across three distinct mechanisms. Brands building a multi-peptide line typically take one from each column rather than several from one.
| Peptide | INCI | Mechanism / category | Positioning |
|---|---|---|---|
| Matrixyl | Palmitoyl Pentapeptide-4 | Matrikine — collagen support | Firmness, skin quality |
| Argireline | Acetyl Hexapeptide-8 | SNAP-25 — expression lines | Category benchmark, broad appeal |
| SNAP-8 | Acetyl Octapeptide-3 | SNAP-25 — expression lines | Premium analogue |
| GHK-Cu | Copper Tripeptide-1 | Copper complex | Hero ingredient, high recognition |
ⓘ We quote multi-peptide orders on a single quotation and ship them together.
For your formulators
Formulation considerations
Matrixyl handles quite differently from the water-soluble peptides. These are the points that come up most often.
Working with Matrixyl
- ● It is lipophilic, not water soluble. The palmitoyl chain that aids skin delivery also limits solubility in water. Neat powder needs a suitable solubilising system — which is why many formulators prefer to buy it as a ready-made solution.
- ● Use levels are very low. It works in the parts-per-million range, so accurate dosing matters more than with most actives. A pre-diluted solution removes a lot of weighing error at production scale.
- ● Add in the cool-down phase. Avoid prolonged high-temperature processing, as with peptides generally.
- ● Colourless. Unlike GHK-Cu it won't tint your base.
- ● Pairs cleanly with expression-line peptides. Different mechanism, no known conflict — the standard combination in multi-peptide serums.
General formulation guidance only. Use levels, stability and compatibility should be validated in your own formulation and stability testing.
Formulation applications
Where Matrixyl is used
- ✓ Anti-ageing serums positioned on firmness and skin quality
- ✓ Collagen-support product lines
- ✓ Eye creams and targeted treatments
- ✓ Night creams and treatment moisturisers
- ✓ Multi-peptide complexes and booster serums
- ✓ Neck and décolletage formulations
- ✓ Private label and white label skincare products
Quality & documentation
Every batch documented
- ✓ GMP-certified manufacturing
- ✓ ISO quality management system
- ✓ HACCP-compliant production controls
- ✓ Independent third-party HPLC testing
- ✓ Certificate of Analysis (COA) issued per batch
- ✓ MSDS available on request
- ✓ Full batch and lot traceability records
Who orders wholesale Matrixyl
Built for cosmetic B2B buyers
Skincare brands
Firmness and collagen-support product formulation.
Private label companies
White label peptide skincare ranges.
Cosmetic manufacturers
Ingredient supply for production runs.
Ingredient distributors
Regional distribution of cosmetic peptides.
Formulation laboratories
R&D and prototype development.
E-commerce beauty brands
Direct-to-consumer peptide skincare.
Request a wholesale Matrixyl quote
Tell us whether you need powder or solution, your target quantity, and any other peptides you're sourcing. We'll reply within 24 hours with pricing and a current batch COA on request.
COAs, bulk pricing and private label options available on request — WhatsApp +44 7880 485232 or email info@sarms-direct.com
Matrixyl FAQs
Frequently asked questions
What is Matrixyl?
What is the CAS number for Matrixyl?
How is Matrixyl different from Argireline or SNAP-8?
Is Matrixyl water soluble?
What is the difference between Matrixyl and Matrixyl 3000?
Do you offer white label Matrixyl supply?
Related cosmetic peptides
Buyers of Matrixyl also order
Argireline →
Acetyl Hexapeptide-8 — the expression-line category benchmark.
SNAP-8 →
Acetyl Octapeptide-3 — premium expression-line analogue.
GHK-Cu →
Copper Tripeptide-1 — the benchmark copper peptide.
Supplied for cosmetic formulation and laboratory research purposes. Not for human consumption. Buyers are responsible for ensuring finished products comply with applicable cosmetics regulations in their market.
