Klotho

Compound Overview

Compound Name	Klotho (α-Klotho)
Gene	KL (Klotho gene)
Compound Class	Longevity-associated protein / FGF23 co-receptor
First Identified	1997 (Makoto Kuro-o et al.)
Primary Function	FGF23 co-receptor; regulation of mineral metabolism, ageing, and organ protection
Purity	≥98% (HPLC & MS verified)
Supply Forms	Sterile vials (lyophilised); predosed pens
Storage	–20°C for long-term storage. Temperature-controlled shipping available.

Available Formats & Supply Options

Klotho Vials
Supplied in sterile, sealed vials in lyophilised powder or solution format. Suitable for wholesale distribution, clinic supply, and research use. Flexible order volumes — contact us for MOQ and pricing based on your quantity and destination market.

Klotho Predosed Pens
Prefilled with sterile Klotho solution. Dial-a-dose mechanism for precision and consistency. No reconstitution required — reduces handling steps and contamination risk. Ideal for clinic supply, wellness brand retail, and multi-site research use. Contact us for dose concentrations, unit quantities, and MOQ.

Private Label & White Label
Custom branding, label design, and packaging available for both vial and pen formats. Ideal for wellness brands and e-commerce operators building their own product lines. Contact us to discuss your requirements.

Research Context

Klotho was originally identified as an ageing suppressor gene — mice deficient in Klotho expression exhibit accelerated ageing phenotypes including shortened lifespan, osteoporosis, arteriosclerosis, skin atrophy, and cognitive decline. Conversely, overexpression of Klotho in animal models has been associated with extended lifespan and protection against age-related pathologies.

In humans, circulating Klotho levels decline with age, and lower levels have been associated with increased risk of cardiovascular disease, chronic kidney disease, cognitive decline, and metabolic dysfunction. Research interest has expanded significantly in recent years, with studies exploring Klotho's roles in neuroprotection, kidney protection, cardiovascular health, and as a potential biomarker and therapeutic target in longevity medicine.

The predosed pen format has made Klotho increasingly accessible for clinic-based research and wellness programmes, particularly in anti-ageing and longevity medicine contexts.

For complementary longevity and cognitive research peptides, visit our sister site Peptide-Direct.

All products are supplied for research purposes only and are not intended for human or veterinary use.

Quality & Documentation

• GMP-certified manufacturing
• ISO quality management system
• HACCP-compliant production controls
• Independent third-party testing — HPLC, MS, ICP-MS
• Certificate of Analysis (COA) issued per batch
• MSDS available on request
• Batch and lot traceability records
• Research Use Only labelling and export documentation included
• Temperature-controlled shipping available

See our Lab Testing & QA page for full methodology detail.

Who Orders Wholesale Klotho

• Distributors — bulk vial and pen supply for regional distribution
• Clinics & anti-ageing practices — predosed pens for client programmes
• Wellness brands — private label vials and pens for longevity product lines
• Online retailers & e-commerce operators — branded Klotho products
• Research institutions — vials for longevity and ageing research programmes
• Private label buyers — custom packaging and branding for Klotho products

See our Industries We Serve page for full B2B client detail.

Related Compounds

Buyers sourcing Klotho frequently also order:

• SNAP-8 — anti-ageing peptide for cosmetic and wellness applications
• Retatrutide — metabolic and weight management research compound, also available as predosed pens
• MK-677 (Ibutamoren) — growth hormone secretagogue, longevity and metabolic research

For longevity peptides including NAD+ precursors, BPC-157, Epithalon, and cognitive compounds, visit our sister site Peptide-Direct.

Frequently Asked Questions

What is Klotho?
Klotho is a longevity-associated protein encoded by the KL gene, first identified in 1997. It functions as a co-receptor for FGF23 and plays a key role in regulating ageing, mineral metabolism, and organ protection. Declining Klotho levels are associated with accelerated ageing, and it is a significant subject of longevity and anti-ageing research.

What formats is wholesale Klotho available in?
Sterile vials (lyophilised or solution) and predosed pens with a dial-a-dose mechanism. Both available for wholesale, private label, and white label supply. Contact us for MOQ and pricing.

Who do you supply wholesale Klotho to?
Distributors, clinics, anti-ageing practices, wellness brands, e-commerce operators, retailers, and private label buyers across Europe and internationally.

Do you offer private label Klotho supply?
Yes. Private label and white label options are available in both vial and pen formats. Contact us to discuss branding and packaging requirements.

Is Klotho the same as NAD+?
No. Klotho is a protein acting as an FGF23 co-receptor. NAD+ is a coenzyme involved in cellular energy metabolism. Both are subjects of longevity research and both are available — NAD+ is available via our sister site Peptide-Direct.

Do you provide COAs for wholesale Klotho?
Yes. A Certificate of Analysis from an independent, accredited laboratory is available for every batch. Full batch documentation included with all orders.

Legal & Safety Notice

Klotho is supplied as a research compound for B2B use only. It is not approved for human consumption, medical treatment, or clinical application by any regulatory authority. Buyers are responsible for ensuring compliance with applicable regulations in their jurisdiction.